Hypothyroidism often results from autoimmune thyroid disease or thyroid resection1
. In the majority of cases, hypothyroidism can be treated effectively by oral thyroid hormone supplementation, most commonly with levothyroxine. Key factors adversely affecting levothyroxine performance have been widely reported in the clinical literature. They include comorbid conditions and their treatments, diet, tolerability of medication and compliance with instructions for administration.
Some patients claim allergies to excipient ingredients found in levothyroxine tablet formulations such as food dyes, wheat starch, talc, etc1. Although their clinical significance is unknown, such allergies may adversely affect patient compliance and satisfaction with therapy.